By default Ziepod+ supports all media formats that are already supported by Windows Media Player(WMP) installed on your computer at the moment. This is because of the fact that Ziepod+ uses DirectShow API which is also used by WMP.
If you install any codec which includes DirectShow filters for supported format, then you can also watch media files in that format via Ziepod+. For example, if you install codec pack called "QuickTime Alternative", since it includes "QuickTime DirectShow filter", you can play files in quicktime format with Ziepod+ and with all other DirectShow supported players, such as WMP.
To learn more about codecs and media formats check help topic and section given below.